TRANSLATIONAL BIOINNOVATION · TAIWAN

Biology with a path to impact.

We connect mitochondrial biology, cellular aging and natural bioactive discovery with clinical questions, reproducible evidence and industry translation.

Meet Prof. Yang Explore the portfolio

EST.20+YEARS OF CONNECTED RESEARCH

PRINCIPAL INVESTIGATOR

Prof. Yu-Lin Yang, Ph.D.

Dean, College of Medical Technology · Professor of Medical Laboratory Science and Biotechnology

A translational scientist and academic leader connecting telomere biology, mitochondrial science, regenerative medicine and biomedical commercialization.

Current appointments

Dean, College of Medical Technology, Chung Hwa University of Medical Technology (since 2021)
Professor, Department of Medical Laboratory Science and Biotechnology / Graduate Institute of Biomedical Science (since 2008)
Joint Professor, Universitas Muhammadiyah Surabaya, Indonesia (since 2026)
Joint Professor, College of Life Sciences, Kaohsiung Medical University (from 2026)

Education & international training

B.S. in Medical Technology and M.S./Ph.D. in Medicine, Kaohsiung Medical University; first-ranked doctoral graduate and recipient of an outstanding dissertation award. Exchange scholar at the University of Queensland under a Taiwan–Australia bilateral program.

Selected leadership & honors

Former Vice President and Dean of Academic Affairs, Chung Hwa University of Medical Technology
Reviewer for national science, education, SBIR and innovation programs
National Teacher of the Year Award, Ministry of Education
International invention awards and long-term national research support

Research focus

Telomere biology & cellular aging
Mitochondrial bioenergetics
Stem-cell & regenerative medicine
Translational natural bioactives

Academic & innovation impact

~60SCI-indexed papers

34invention patent filings

20+years of connected research

2018National Teacher of the Year

What we do

Build evidence across mechanisms, cells, disease models and translational settings.

What we have

Longitudinal research platforms in NRF1, mitochondria, telomeres, MSCs and natural bioactives.

What we seek

Hospitals, international laboratories, CROs, manufacturers and venture partners.

How to collaborate

Joint R&D · validation · clinical translation · technology transfer · product development.

FIVE WAYS IN

Start with the problem you want to solve.

Our portfolio is organized around collaboration outcomes—not filing cabinets.

SELECTED PROJECTS

Evidence, readiness and the next useful partner.

Every public summary is intentionally conservative. Proposal-stage work is not presented as an awarded or completed program.

RESEARCH GALAXY

Explore the orbit of questions, methods and translation.

Hover or click a galaxy. Lock-on focus reveals its research signal.

楊堉麟PRINCIPAL INVESTIGATOR

2027Proposal

Regenerative Medicine

NRF × MSC Rejuvenation Platform

A translational program exploring how natural regenerative signaling may support measurable MSC quality and cellular resilience.

Validation-ready concept

2027To confirm

Neuroscience & Healthy Aging

Taiwan–Singapore Dementia Collaboration

An international collaboration concept for aligning dementia questions, biomarkers and complementary research platforms.

International concept

2026Proposal

Technology Commercialization

HerboChip Functional-guided Screening & Knowledge Transfer

A two-decade functional-guided discovery workflow is being organized into a reproducible, teachable and industry-auditable platform.

Established platform · transfer plan proposed

2026Proposal

Neuroscience & Healthy Aging

Mitochondrial Activation for Post-stroke Neural Repair

A proposed basic–clinical collaboration centered on mitochondrial dysfunction, oxidative stress and loss of neural plasticity after ischemic injury.

Pilot-study design

2026To confirm

Neuroscience & Healthy Aging

NRF-linked Healthy Aging & Dementia Research

A developing research direction connecting cellular resilience and aging biology with dementia-relevant questions.

Research concept to confirm

2026Proposal

Translational & Clinical Research

APOE-informed Dementia Translation

A clinically governed research concept using APOE-informed stratification to sharpen dementia and healthy-aging questions.

Protocol development

2026Active

Translational & Clinical Research

NRF1, Mitophagy & Lung-cancer Response

An active disease-model program examining how NRF1-linked mitochondrial quality control may shape lung-cancer treatment response.

Active disease-model research

2026Proposal

Technology Commercialization

2D-to-3D Stem-cell Translation Platform

A proposed industry-facing platform for comparing stem-cell culture formats through reproducible functional performance.

Proposal with validation framework

2026Proposal

Technology Commercialization

Regenerative Technology Venture Creation

A venture-oriented pathway for converting a research platform into evidence gates, partner roles and a credible route to use.

Commercialization proposal

2025–2026Active

Regenerative Medicine

NRF1, Telomere Regulation & Stem-cell Function

Mechanism-led research connecting NRF1, telomere maintenance and mitochondrial homeostasis with functional stem-cell outcomes.

Active research platform

2017–2026Active

Translational & Clinical Research

Mitochondrial Biology in Cancer Models

A sustained research portfolio using mitochondrial regulation and cellular stress biology to investigate cancer progression and treatment response.

Established disease-model portfolio

99 (2010)Completed

Translational & Clinical Research

Role of TSLP shRNA in the Inhibition of Pulmonary Fibrosis and Its Clinical Applications

Role of TSLP shRNA in the Inhibition of Pulmonary Fibrosis and Its Clinical Applications | Public GRB research record (PG9911-0306)

Completed / historical record

99 (2010)Completed

Regenerative Medicine

Induction of Bone Growth by Implanting Allogeneic Mesenchymal Stem Cells Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model

Induction of Bone Growth by Implanting Allogeneic Mesenchymal Stem Cells Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model | Public GRB research record (PC9902-1833)

Completed / historical record

99 (2010)Completed

Translational & Clinical Research

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications | Public GRB research record (PC9907-2572)

Completed / historical record

98 (2009)Completed

Regenerative Medicine

Induction of Bone Growth by Implanting Allogeneic Mesenchymal Stem Cells Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model

Induction of Bone Growth by Implanting Allogeneic Mesenchymal Stem Cells Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model | Public GRB research record (PC9808-0783)

Completed / historical record

98 (2009)Completed

Technology Commercialization

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms | Public GRB research record (PC9801-1885)

Completed / historical record

97 (2008)Completed

Regenerative Medicine

BMP-2 Gene Therapy for Rabbit Spinal Fusion: Optimal Implanted Cell Numbers (Part I) and Identification of BMP-2 Sources (Part II)

BMP-2 Gene Therapy for Rabbit Spinal Fusion: Optimal Implanted Cell Numbers (Part I) and Identification of BMP-2 Sources (Part II) | Public GRB research record (PC9706-0579)

Completed / historical record

97 (2008)Completed

Technology Commercialization

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms | Public GRB research record (PC9706-1021)

Completed / historical record

96 (2007)Completed

Regenerative Medicine

Part I: BMP-2 Gene Therapy for Rabbit Spinal Fusion; Part II: Identification of BMP-2 Sources

Part I: BMP-2 Gene Therapy for Rabbit Spinal Fusion; Part II: Identification of BMP-2 Sources | Public GRB research record (PC9607-0915)

Completed / historical record

96 (2007)Completed

Technology Commercialization

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms | Public GRB research record (PC9609-4589)

Completed / historical record

95 (2006)Completed

Translational & Clinical Research

Therapeutic Role of Bone Morphogenetic Protein-2 in Diabetic Renal Fibrosis

Therapeutic Role of Bone Morphogenetic Protein-2 in Diabetic Renal Fibrosis | Public GRB research record (PC9508-1150)

Completed / historical record

95 (2006)Completed

Regenerative Medicine

Analysis of Extracorporeal Shockwave-Enhanced BMP-2 Expression at Spinal Fusion Sites

Analysis of Extracorporeal Shockwave-Enhanced BMP-2 Expression at Spinal Fusion Sites | Public GRB research record (PC9508-0997)

Completed / historical record

94 (2005)Completed

Translational & Clinical Research

Dual Inhibition Strategy Using an Angiotensin Inhibitor and TGF-β Receptor Interfering RNA

Dual Inhibition Strategy Using an Angiotensin Inhibitor and TGF-β Receptor Interfering RNA | Public GRB research record (PC9408-1906)

Completed / historical record

93 (2004)Completed

Translational & Clinical Research

Suppression of High-Glucose-Induced Renal Cell Fibrosis through Regulation of TGF-β Receptor Expression by Atypical PKC

Suppression of High-Glucose-Induced Renal Cell Fibrosis through Regulation of TGF-β Receptor Expression by Atypical PKC | Public GRB research record (PC9308-1293)

Completed / historical record

92 (2003)Completed

Translational & Clinical Research

Roles of CD36 and Post-Receptor Signaling Pathways in the Treatment of Diabetic Renal Fibrosis

Roles of CD36 and Post-Receptor Signaling Pathways in the Treatment of Diabetic Renal Fibrosis | Public GRB research record (PC9208-0110)

Completed / historical record

91 (2002)Completed

Translational & Clinical Research

Reversal of Advanced Glycation End Product-Induced Thrombospondin-1 Overexpression Using a Transcription-Factor Decoy

Reversal of Advanced Glycation End Product-Induced Thrombospondin-1 Overexpression Using a Transcription-Factor Decoy | Public GRB research record (PC9108-1722)

Completed / historical record

90 (2001)Completed

Translational & Clinical Research

Roles of Transcription Factors AP-1 and NF-κB in High-Glucose-Induced TGF-β Receptor Expression in Renal Tubular Cells

Roles of Transcription Factors AP-1 and NF-κB in High-Glucose-Induced TGF-β Receptor Expression in Renal Tubular Cells | Public GRB research record (PC9008-0265)

Completed / historical record

2026To confirm

Technology Commercialization

NRF Regenerative Dressing Translation

A translation pathway for pairing regenerative material concepts with structured cellular validation and product-development evidence.

Translation pathway to confirm

2026Idea

AI × Precision Medicine

AI-assisted Biomedical Evidence Design

An exploratory direction for using governed AI workflows to organize evidence, prioritize biomarkers and improve study design.

Exploratory concept

2024–2026Active

Translational & Clinical Research

Hospital & IRB Translation Platform

A collaboration capability for translating mechanistic questions into ethically governed, clinically meaningful research designs.

Operational collaboration experience

2023–2025Completed

Translational & Clinical Research

Functional Ingredient & Telomere Validation

Completed collaboration experience applying telomere and functional endpoints to diverse natural and functional materials.

Completed validation experience

115 (2026)Active

Translational & Clinical Research

Effects of NRF1 Combined with Clinical Drugs on Mitophagy and Therapeutic Response in Lung Cancer Cells

Effects of NRF1 Combined with Clinical Drugs on Mitophagy and Therapeutic Response in Lung Cancer Cells | Public GRB research record (PG11504-0064)

Recent / active record

114 (2025)Active

Regenerative Medicine

NRF-Mediated Telomere Regulation, Stem-Cell Proliferation and Differentiation, and Applications in Regenerative Medicine

NRF-Mediated Telomere Regulation, Stem-Cell Proliferation and Differentiation, and Applications in Regenerative Medicine | Public GRB research record (PF11408-3650)

Recent / active record

114 (2025)Active

Translational & Clinical Research

Effects of Mitochondrial Biogenesis on Tumor Development and Therapy in the SCID Mouse A549 Lung Cancer Model

Effects of Mitochondrial Biogenesis on Tumor Development and Therapy in the SCID Mouse A549 Lung Cancer Model | Public GRB research record (PG11403-0101)

Recent / active record

113 (2024)Completed

Translational & Clinical Research

Effects of Lung Cancer Cell Invasiveness, Epithelial-Mesenchymal Transition and Cellular Energy Regulation on Tumor Development

Effects of Lung Cancer Cell Invasiveness, Epithelial-Mesenchymal Transition and Cellular Energy Regulation on Tumor Development | Public GRB research record (PG11401-0064)

Completed / historical record

108 (2019)Completed

Translational & Clinical Research

Roles of Microparticles and Neuropilin-1 in the Regulation of Renal Fibrosis

Roles of Microparticles and Neuropilin-1 in the Regulation of Renal Fibrosis | Public GRB research record (PC10807-5642)

Completed / historical record

106 (2017)Completed

Translational & Clinical Research

Interactions among ROS, Endoplasmic Reticulum Stress and Mitochondrial Biogenesis in TGF-β1-Stimulated Glomerular Podocytes

Interactions among ROS, Endoplasmic Reticulum Stress and Mitochondrial Biogenesis in TGF-β1-Stimulated Glomerular Podocytes | Public GRB research record (PC10608-1494)

Completed / historical record

105 (2016)Completed

Translational & Clinical Research

Role of the Mitochondrial Biogenesis Transcription Factor NRF-1 in the Regulation and Treatment of Renal Fibrosis

Role of the Mitochondrial Biogenesis Transcription Factor NRF-1 in the Regulation and Treatment of Renal Fibrosis | Public GRB research record (PC10507-1004)

Completed / historical record

103 (2014)Completed

Technology Commercialization

Regulatory Roles and Mechanisms of Diosgenin and AMPK/SIRT1/PGC-1 in Renal Fibrosis

Regulatory Roles and Mechanisms of Diosgenin and AMPK/SIRT1/PGC-1 in Renal Fibrosis | Public GRB research record (PC10308-1858)

Completed / historical record

101 (2012)Completed

Translational & Clinical Research

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications | Public GRB research record (PC10101-1477)

Completed / historical record

100 (2011)Completed

Translational & Clinical Research

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications | Public GRB research record (PC10001-1085)

Completed / historical record

PUBLICATIONS

Follow the research through its published record.

49 public PubMed records are organized by research signal. Filter a direction, search a concept, then open the original article record.

49 records shown · each entry links to PubMed

2026

Cancer, Mitochondria & Cell Plasticity

NRF1 Activates the AMPK/SIRT1/PGC-1α/TFAM Axis to Suppress EMT and Tumor Progression in Lung Adenocarcinoma.

Cancer Genomics & Proteomics

Biology with a path to impact.

Prof. Yu-Lin Yang, Ph.D.

Current appointments

Education & international training

Selected leadership & honors

Research focus

What we do

What we have

What we seek

How to collaborate

Start with the problem you want to solve.

Evidence, readiness and the next useful partner.

Explore the orbit of questions, methods and translation.

NRF × MSC Rejuvenation Platform

Taiwan–Singapore Dementia Collaboration

HerboChip Functional-guided Screening & Knowledge Transfer

Mitochondrial Activation for Post-stroke Neural Repair

NRF-linked Healthy Aging & Dementia Research

APOE-informed Dementia Translation

NRF1, Mitophagy & Lung-cancer Response

2D-to-3D Stem-cell Translation Platform

Regenerative Technology Venture Creation

NRF1, Telomere Regulation & Stem-cell Function

Mitochondrial Biology in Cancer Models

Role of TSLP shRNA in the Inhibition of Pulmonary Fibrosis and Its Clinical Applications

Induction of Bone Growth by Implanting Allogeneic Mesenchymal Stem Cells Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications

Induction of Bone Growth by Implanting Allogeneic Mesenchymal Stem Cells Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms

BMP-2 Gene Therapy for Rabbit Spinal Fusion: Optimal Implanted Cell Numbers (Part I) and Identification of BMP-2 Sources (Part II)

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms

Part I: BMP-2 Gene Therapy for Rabbit Spinal Fusion; Part II: Identification of BMP-2 Sources

Herbal Medicine Chip-Guided Investigation of Natural Products for Anti-Renal-Fibrosis Activity and TGF-β/Smad Mechanisms

Therapeutic Role of Bone Morphogenetic Protein-2 in Diabetic Renal Fibrosis

Analysis of Extracorporeal Shockwave-Enhanced BMP-2 Expression at Spinal Fusion Sites

Dual Inhibition Strategy Using an Angiotensin Inhibitor and TGF-β Receptor Interfering RNA

Suppression of High-Glucose-Induced Renal Cell Fibrosis through Regulation of TGF-β Receptor Expression by Atypical PKC

Roles of CD36 and Post-Receptor Signaling Pathways in the Treatment of Diabetic Renal Fibrosis

Reversal of Advanced Glycation End Product-Induced Thrombospondin-1 Overexpression Using a Transcription-Factor Decoy

Roles of Transcription Factors AP-1 and NF-κB in High-Glucose-Induced TGF-β Receptor Expression in Renal Tubular Cells

NRF Regenerative Dressing Translation

AI-assisted Biomedical Evidence Design

Hospital & IRB Translation Platform

Functional Ingredient & Telomere Validation

Effects of NRF1 Combined with Clinical Drugs on Mitophagy and Therapeutic Response in Lung Cancer Cells

NRF-Mediated Telomere Regulation, Stem-Cell Proliferation and Differentiation, and Applications in Regenerative Medicine

Effects of Mitochondrial Biogenesis on Tumor Development and Therapy in the SCID Mouse A549 Lung Cancer Model

Effects of Lung Cancer Cell Invasiveness, Epithelial-Mesenchymal Transition and Cellular Energy Regulation on Tumor Development

Roles of Microparticles and Neuropilin-1 in the Regulation of Renal Fibrosis

Interactions among ROS, Endoplasmic Reticulum Stress and Mitochondrial Biogenesis in TGF-β1-Stimulated Glomerular Podocytes

Role of the Mitochondrial Biogenesis Transcription Factor NRF-1 in the Regulation and Treatment of Renal Fibrosis

Regulatory Roles and Mechanisms of Diosgenin and AMPK/SIRT1/PGC-1 in Renal Fibrosis

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications

Role of Thymic Stromal Lymphopoietin in Diabetic Nephropathy and Its Anti-fibrotic Clinical Applications

Follow the research through its published record.

NRF1 Activates the AMPK/SIRT1/PGC-1α/TFAM Axis to Suppress EMT and Tumor Progression in Lung Adenocarcinoma.

Verbascoside Suppresses Epithelial-Mesenchymal Transition and Mitochondrial Biogenesis by Targeting Anti-senescence Signaling in Castration-resistant Prostate Cancer.

SCAMP3 and EPS8 Cooperatively Regulate EGFR Signaling to Promote Enzalutamide Resistance and Metastatic Potential in Prostate Cancer.

Rutin Suppresses EMT and Induces Mitochondrial Biogenesis via ER Stress-linked AMPK/SIRT1 Signaling in Prostate Cancer Cells.

The Regulatory Role of Nuclear Respiratory Factor 1 in Bladder Cancer Cells.

Nuclear Respiratory Factor 1 Overexpression Inhibits Proliferation and Migration of PC3 Prostate Cancer Cells.

Verbascoside inhibits the epithelial-mesenchymal transition of prostate cancer cells through high-mobility group box 1/receptor for advanced glycation end-products/TGF-β pathway.

Macrophage migration inhibitory factor regulates integrin-β1 and cyclin D1 expression via ERK pathway in podocytes.

Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling.

Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action.

Crosstalk between transforming growth factor-β1 and endoplasmic reticulum stress regulates alpha-smooth muscle cell actin expression in podocytes.

TGF-β1 modulates podocyte migration by regulating the expression of integrin-β1 and -β3 through different signaling pathways.

Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis.

Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis.

Treatment with cytokine thymic stromal lymphopoietin short hairpin RNA substantially reduces TGF-β1-induced interstitial cellular fibrosis.

Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.

Antihypertensive action of allantoin in animals.

The effects of diosgenin in the regulation of renal proximal tubular fibrosis.

Polymerase chain reaction as the sole diagnostic tool for sacral-spinal tuberculosis.

Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.

Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad- and epithelial-mesenchymal transition signaling pathways.

Design, fabrication, and characterization of Si-based ARROW photonic crystal bend waveguides and power splitters.

20-Hydroxyecdysone attenuates TGF-β1-induced renal cellular fibrosis in proximal tubule cells.

The role of IL-7 in renal proximal tubule epithelial cells fibrosis.

BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition.